Compared with SSRIs/SNRIs, bupropion tends to have what profile regarding sexual side effects?

Compared with SSRIs/SNRIs, bupropion tends to have what profile regarding sexual side effects?

• A. More sexual side effects
• B. Fewer sexual side effects
• C. No sexual side effects
• D. Sexual side effects are unpredictable

Answer: (B)

Sexual side effects from antidepressants are largely driven by how they affect serotonin. SSRIs and SNRIs boost serotonin activity, which can dampen libido, arousal, and orgasm for many people. Bupropion works mainly by increasing dopamine and norepinephrine, with little serotonergic activity, so it tends not to disrupt sexual function in the same way. In fact, some patients may experience improvement in sexual function when using bupropion. So, relative to SSRIs/SNRIs, it generally has fewer sexual side effects. Keep in mind that individual responses vary, and bupropion can bring other effects like insomnia or anxiety in some cases.

Sexual side effects from antidepressants are largely driven by how they affect serotonin. SSRIs and SNRIs boost serotonin activity, which can dampen libido, arousal, and orgasm for many people. Bupropion works mainly by increasing dopamine and norepinephrine, with little serotonergic activity, so it tends not to disrupt sexual function in the same way. In fact, some patients may experience improvement in sexual function when using bupropion. So, relative to SSRIs/SNRIs, it generally has fewer sexual side effects. Keep in mind that individual responses vary, and bupropion can bring other effects like insomnia or anxiety in some cases.